Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin

Abstract

The side chain of the antifungal antibiotic ansatrienin A from Streptomyces collinus contains a cyclohexanecarboxylic acid (CHC)-derived moiety. This moiety is also observed in trace amounts of ω-cyclohexyl fatty acids (typically less than 1% of total fatty acids) produced by S. collinus. Coenzyme A-activated CHC (CHC-CoA) is derived from shikimic acid… (More)
DOI: 10.1038/79479

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