Identification of a cryptic nucleolar-localization signal in MDM2

@article{Lohrum2000IdentificationOA,
  title={Identification of a cryptic nucleolar-localization signal in MDM2},
  author={M. A. Lohrum and M. Ashcroft and M. Kubbutat and K. Vousden},
  journal={Nature Cell Biology},
  year={2000},
  volume={2},
  pages={179-181}
}
  • M. A. Lohrum, M. Ashcroft, +1 author K. Vousden
  • Published 2000
  • Biology, Medicine
  • Nature Cell Biology
  • he tumour suppressor protein p53 is a potent inhibitor of cell growth, activating both cell-cycle arrest and apoptotic pathways in stressed cells. One of the principal regulators of p53 function and stability is the MDM2 protein, which can target p53 for ubiquitin-dependent degradation by the proteasome, as well as regulating its own stability. p53 is stabilized in response to stress through several mechanisms, including the expression of ARF (p14 in humans and p19 in mouse) in response to… CONTINUE READING
    199 Citations
    Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex
    • 284
    • PDF
    The MDM2-p53 interaction.
    • 691
    ARF Impedes NPM/B23 Shuttling in an Mdm2-Sensitive Tumor Suppressor Pathway
    • 168
    • Highly Influenced
    • PDF
    Regulation of p53 and MDM2 Activity by MTBP
    • 58
    • PDF
    Ribosomal protein S7 is both a regulator and a substrate of MDM2.
    • 178
    The MDM 2p 53 Interaction
    • 50
    • PDF
    The Regulation of Multiple p53 Stress Responses is Mediated through MDM2.
    • 92
    Physical and Functional Interactions of the Arf Tumor Suppressor Protein with Nucleophosmin/B23
    • 394
    • PDF

    References

    SHOWING 1-10 OF 17 REFERENCES
    Analysis of the degradation function of Mdm2.
    • 114
    • PDF
    Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.
    • 961
    • PDF
    p14ARF links the tumour suppressors RB and p53
    • 966
    Nucleolar Arf sequesters Mdm2 and activates p53
    • 941
    P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2.
    • W. Tao, A. Levine
    • Medicine, Biology
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1999
    • 584
    • PDF
    Keeping an old friend under control: regulation of p53 stability.
    • 125