Identification of a cryptic nucleolar-localization signal in MDM2

  title={Identification of a cryptic nucleolar-localization signal in MDM2},
  author={M. A. Lohrum and M. Ashcroft and M. Kubbutat and K. Vousden},
  journal={Nature Cell Biology},
  • M. A. Lohrum, M. Ashcroft, +1 author K. Vousden
  • Published 2000
  • Biology, Medicine
  • Nature Cell Biology
  • he tumour suppressor protein p53 is a potent inhibitor of cell growth, activating both cell-cycle arrest and apoptotic pathways in stressed cells. One of the principal regulators of p53 function and stability is the MDM2 protein, which can target p53 for ubiquitin-dependent degradation by the proteasome, as well as regulating its own stability. p53 is stabilized in response to stress through several mechanisms, including the expression of ARF (p14 in humans and p19 in mouse) in response to… CONTINUE READING
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