Identification of a consensus element recognized and cleaved by IRE1α

@inproceedings{Oikawa2010IdentificationOA,
  title={Identification of a consensus element recognized and cleaved by IRE1α},
  author={Daisuke Oikawa and Mio Tokuda and Akira Hosoda and Takao Iwawaki},
  booktitle={Nucleic acids research},
  year={2010}
}
IRE1α is an endoplasmic reticulum (ER)-located transmembrane RNase that plays a central role in the ER stress response. Upon ER stress, IRE1α is activated and cleaves specific exon-intron sites in the mRNA encoding the transcription factor X-box-binding protein 1 (XBP1). In addition, previous studies allow us to predict that IRE1α targets several RNAs other than the XBP1. In fact, we have identified CD59 mRNA as a cleavage target of IRE1α. However, it is not yet clear how IRE1α recognizes and… CONTINUE READING