Identification of a compound short tandem repeat stretch in the 5′-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia

@article{Hattori2001IdentificationOA,
  title={Identification of a compound short tandem repeat stretch in the 5′-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia},
  author={Eiji Hattori and Mitsuru Ebihara and Kiyofumi Yamada and Hisako Ohba and Haruo Shibuya and Takeo Yoshikawa},
  journal={Molecular Psychiatry},
  year={2001},
  volume={6},
  pages={465-470}
}
The cholecystokinin gene (CCK) is thought to play a role in the pathogenesis of both panic disorder1–4 and schizophrenia.5 In this study, we have extended the 5′-upstream sequence of the CCK gene, and identified a compound short tandem repeat (STR), located approximately −2.2 to −1.8 kb from the cap site. This STR was found to be polymorphic with ten different allele lengths. Case-control studies using 73 panic patients, 305 schizophrenics and 252 controls showed a significant allelic… CONTINUE READING
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