Identification of a common sphingolipid-binding domain in Alzheimer, prion, and HIV-1 proteins.

  title={Identification of a common sphingolipid-binding domain in Alzheimer, prion, and HIV-1 proteins.},
  author={Radhia Mahfoud and Nicolas Garmy and Marc Maresca and Nouara Yahi and Antoine Puigserver and Jacques Fantini},
  journal={The Journal of biological chemistry},
  volume={277 13},
The V3 loop of the human immunodeficiency virus (HIV)-1 surface envelope glycoprotein gp120 is a sphingolipid-binding domain mediating the attachment of HIV-1 to plasma membrane microdomains (rafts). Sphingolipid-induced conformational changes in gp120 are required for HIV-1 fusion. Galactosylceramide and sphingomyelin have been detected in highly purified preparations of prion rods, suggesting that the prion protein (PrP) may interact with selected sphingolipids. Moreover, a major… CONTINUE READING


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