Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.

@article{Schweinfest1993IdentificationOA,
  title={Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas.},
  author={Clifford W. Schweinfest and Kelly W. Henderson and Saul M Suster and Nobuo Kondoh and Takis S. Papas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 9},
  pages={4166-70}
}
A cDNA, which we call DRA (for down-regulated in adenoma) has been isolated. Its mRNA is expressed exclusively in normal colon tissue, probably only in the mucosal epithelia. Expression of the DRA gene is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon. The DRA gene appears to be a single-copy gene present on chromosome 7, a chromosome associated with colorectal tumorigenesis. The predicted DRA polypeptide is an 84,500-Da protein that contains charged clusters of… CONTINUE READING

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