Identification of a cold receptor reveals a general role for TRP channels in thermosensation

@article{McKemy2002IdentificationOA,
  title={Identification of a cold receptor reveals a general role for TRP channels in thermosensation},
  author={David D. McKemy and Werner M. Neuhausser and David Julius},
  journal={Nature},
  year={2002},
  volume={416},
  pages={52-58}
}
The cellular and molecular mechanisms that enable us to sense cold are not well understood. Insights into this process have come from the use of pharmacological agents, such as menthol, that elicit a cooling sensation. Here we have characterized and cloned a menthol receptor from trigeminal sensory neurons that is also activated by thermal stimuli in the cool to cold range. This cold- and menthol-sensitive receptor, CMR1, is a member of the TRP family of excitatory ion channels, and we propose… 
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Differences in the expression of TRPM8 channels among populations of cold-sensitive neurons are revealed and an overlapping function with other molecular cold sensors in thermoreceptor terminals is suggested.
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TLDR
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TLDR
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TLDR
This mini-review gives a brief overview of the way by which ion channels contribute to cold sensation, discusses the controversy around the cold-sensitivity of TRPA1, and provides an assessment of some recently-proposed novel cold-transduction mechanisms.
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TLDR
A summary of some the most relevant biophysical properties, physiological role, and molecular intimacies of this polymodal thermoTRP channel are presented.
93 MOLECULAR MECHANISMS OF COLD SENSING BY TRP CHANNELS
There is still controversy about the role played by various ionic channels in the excitation of cold thermoreceptors and nociceptive neurons by cooling stimuli (Reid, 2005). Electrophysiological and
Therapeutic Potential of TRPM 8 Modulators
The perception of temperature is a key tenet of sensory physiology and is critical in not only acute responses to changes in our environment, but also fundamental in regulating homeostatic mechanisms
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TLDR
The afferent neurocircuits underlying temperature sensation are elucidated, continuing the rapid expansion in understanding of the cellular and molecular basis of thermosensation that began with the discovery of TRPV1 and TRPM8.
TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat
TLDR
Evidence is provided that TRPM3 functions as a chemo- and thermosensor in the somatosensory system and an unanticipated role for TR PM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat is revealed.
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