Identification of a class of chromatin boundary elements.

@article{Cuvier1998IdentificationOA,
  title={Identification of a class of chromatin boundary elements.},
  author={Olivier Cuvier and Craig M. Hart and U. K. Laemmli},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 12},
  pages={7478-86}
}
Boundary elements are thought to define the ends of functionally independent domains of genetic activity. An assay for boundary activity based on this concept measures the ability to insulate a bracketed, chromosomally integrated reporter gene from position effects. Despite their presumed importance, the few examples identified to date apparently do not share sequence motifs or DNA binding proteins. The Drosophila protein BEAF binds the scs' boundary element of the 87A7 hsp70 locus and roughly… CONTINUE READING

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and protects against position effect in Drosophila

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