Identification of a cis-acting element that localizes mRNA to synapses.

  title={Identification of a cis-acting element that localizes mRNA to synapses.},
  author={Elliott J Meer and Dan Wang and Sangmok Kim and Ian Barr and Feng Guo and Kelsey C Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 12},
Messenger RNA (mRNA) localization and regulated translation can spatially restrict gene expression to each of the thousands of synaptic compartments formed by a single neuron. Although cis-acting RNA elements have been shown to direct localization of mRNAs from the soma into neuronal processes, less is known about signals that target transcripts specifically to synapses. In Aplysia sensory-motor neuronal cultures, synapse formation rapidly redistributes the mRNA encoding the peptide… CONTINUE READING


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