Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein.

Abstract

Cleavage after Met596 of the beta-amyloid precursor protein to generate the N-terminus of beta-protein indicates the activity of a protease having chymotrypsin-like specificity. A chymotrypsin-like protease is further implicated in Alzheimer's disease by the increased synthesis of the protease inhibitor alpha 1-antichymotrypsin in pathologically affected… (More)

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Cite this paper

@article{Nelson1993IdentificationOA, title={Identification of a chymotrypsin-like mast cell protease in rat brain capable of generating the N-terminus of the Alzheimer amyloid beta-protein.}, author={Ramona Nelson and Renato R. Siman and M. A. Iqbal and Hollis Potter}, journal={Journal of neurochemistry}, year={1993}, volume={61 2}, pages={567-77} }