Identification of a cell-surface protein involved in PC12 cell-substratum adhesion and neurite outgrowth on laminin and collagen.

@article{Turner1989IdentificationOA,
  title={Identification of a cell-surface protein involved in PC12 cell-substratum adhesion and neurite outgrowth on laminin and collagen.},
  author={David Curtis Turner and L. A. Flier and Salvatore Carbonetto},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1989},
  volume={9 9},
  pages={
          3287-96
        }
}
On substrata coated with laminin or native collagen (Types I/III), PC12 cells employ an active adhesion mechanism (i.e., one inhibited at low temperature, by azide or in the absence of divalent cations) to attach and extend neurites; on substrata coated with wheat germ agglutinin (WGA) or polylysine, by contrast, PC12 cells attach via a passive mechanism and fail to extend neurites (Turner et al., 1987). This paper reports the isolation of 2 monoclonal antibodies (3A3 and 1B1) that promote… CONTINUE READING

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