Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines.

@article{Tang2002IdentificationOA,
  title={Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines.},
  author={Terence C-M Tang and Jonathan Shun-Tong Sham and Dan Xie and Yan Fang and Ke-ke Huo and Qiu-liang Wu and Xinyuan Guan},
  journal={Cancer research},
  year={2002},
  volume={62 24},
  pages={7157-61}
}
High-level amplification of DNA sequence at 19q13.1 is one of the frequent genetic alterations in ovarian cancer. In an attempt to verify the minimal amplified region (MAR) at 19q13.1 and to identify the target oncogenes, 49 probes within a region from D19S425 to D19S907 ( approximately 19.5 cM) were used to survey the amplification status in four ovarian cancer cell lines that have been confirmed as containing amplification at 19q13.1. Two separated overlapping MARs, MAR1 (approximately 200 kb… CONTINUE READING

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