Identification of a candidate gene for astigmatism.

  title={Identification of a candidate gene for astigmatism.},
  author={Margarida Chagas Lopes and Pirro G Hysi and Virginie J M Verhoeven and Stuart Macgregor and Alex W. Hewitt and Grant W. Montgomery and Phillippa Cumberland and Johannes R. Vingerling and Terri L Young and Cornelia M van Duijn and Ben A. Oostra and Andr{\'e} G. Uitterlinden and J S Rahi and David A Mackey and Caroline C. W. Klaver and Toby Andrew and Christopher J Hammond},
  journal={Investigative ophthalmology & visual science},
  volume={54 2},
PURPOSE Astigmatism is a common refractive error that reduces vision, where the curvature and refractive power of the cornea in one meridian are less than those of the perpendicular axis. It is a complex trait likely to be influenced by both genetic and environmental factors. Twin studies of astigmatism have found approximately 60% of phenotypic variance is explained by genetic factors. This study aimed to identify susceptibility loci for astigmatism. METHODS We performed a meta-analysis of… CONTINUE READING
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