Identification of a calmodulin-dependent protein kinase in the cardiac cytosol, which phosphorylates phospholamban in the sarcoplasmic reticulum.

@article{Iwasa1985IdentificationOA,
  title={Identification of a calmodulin-dependent protein kinase in the cardiac cytosol, which phosphorylates phospholamban in the sarcoplasmic reticulum.},
  author={Tatsuo Iwasa and Noboru Inoue and Eishichi Miyamoto},
  journal={Journal of biochemistry},
  year={1985},
  volume={98 2},
  pages={
          577-80
        }
}
A multifunctional calmodulin-dependent protein kinase in the canine cardiac cytosol was purified to near homogeneity. The purified enzyme inactivated glycogen synthase by means of phosphorylation. The enzyme also phosphorylated phospholamban and several other proteins. In view of its physicochemical properties and substrate specificity, the enzyme differed from myosin light chain kinase and phosphorylase kinase, and was considered to belong to a class of similar calmodulin-dependent protein… CONTINUE READING