Identification of a calcium-inducible, epidermal-specific regulatory element in the 3'-flanking region of the human keratin 1 gene.

@article{Rothnagel1993IdentificationOA,
  title={Identification of a calcium-inducible, epidermal-specific regulatory element in the 3'-flanking region of the human keratin 1 gene.},
  author={Joseph A. Rothnagel and David A. Greenhalgh and T A Gagne and Mary Ann Longley and Dennis R. Roop},
  journal={The Journal of investigative dermatology},
  year={1993},
  volume={101 4},
  pages={506-13}
}
Previous studies have shown that the process of epidermal differentiation is profoundly influenced by the level of intracellular calcium within keratinocytes. In this study we have identified a 249-bp region, located 7.9 kb downstream from the promoter of the human keratin 1 (HK1) gene, that is able to activate a SV40 minimal promoter chloramphenicol acetyl transferase (CAT) construct in transfected murine keratinocytes. This activity was potentiated by increased levels of calcium and was… CONTINUE READING
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