Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing.

@article{Ji1997IdentificationOA,
  title={Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing.},
  author={Huiling Ji and Yiliang Ellie Liu and Taiping Jia and Ming-rong Wang and Jin-fen Liu and Guanghua Xiao and Boby K. Joseph and Craig Rosen and Yuenian Eric Shi},
  journal={Cancer research},
  year={1997},
  volume={57 4},
  pages={759-64}
}
A high-throughput direct-differential cDNA sequencing approach was employed to identify genes differentially expressed in normal breast as compared with breast cancer. Approximately 6000 expressed sequence tags (ESTs) from cDNA libraries of normal breast and breast carcinoma were selected randomly and subjected to EST-sequencing analysis. The relative expression levels of more than 2000 unique EST groups were quantitatively compared in normal versus cancerous breast. Of many putative… CONTINUE READING
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