Identification of a bovine coronavirus packaging signal.

  title={Identification of a bovine coronavirus packaging signal.},
  author={R Cologna and Brenda G Hogue},
  journal={Journal of virology},
  volume={74 1},
A region of the bovine coronavirus (BCV) genome that functions as a packaging signal has been cloned. The 291-nucleotide clone shares 72% homology with the region of mouse hepatitis coronavirus (MHV) gene 1b that contains the packaging signal. RNA transcripts were packaged into both BCV and MHV virions when the cloned region was appended to a noncoronavirus RNA. This is the first identification of a BCV packaging signal. The data demonstrate that the BCV genome contains a sequence that is… CONTINUE READING