Identification of a biological inactive complex form of pokeweed antiviral protein.

@article{Desvoyes1997IdentificationOA,
  title={Identification of a biological inactive complex form of pokeweed antiviral protein.},
  author={B{\'e}n{\'e}dicte Desvoyes and J L Poyet and Jana Schlick and Paulo Fernando Adami and Mich{\`e}le Jouvenot and Philippe Dulieu},
  journal={FEBS letters},
  year={1997},
  volume={410 2-3},
  pages={
          303-8
        }
}
Pokeweed antiviral protein (PAP) inactivates both eukaryotic and prokaryotic ribosomes via a specific depurination of rRNA. The sensitivity of pokeweed ribosomes to PAP implies the existence of a mechanism to protect the plant. Using monoclonal antibodies specific to PAP, a protein complex (PAPi) which contained PAP was identified in leaf extract. In this complex, the enzymatic activity of the toxin was strongly inhibited. This protein complex had a pI lower than that of PAP and was separated… CONTINUE READING