Identification of a ZP3-binding protein on acrosome-intact mouse sperm by photoaffinity crosslinking.

@article{Bleil1990IdentificationOA,
  title={Identification of a ZP3-binding protein on acrosome-intact mouse sperm by photoaffinity crosslinking.},
  author={Jan Bleil and Paul M. Wassarman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 14},
  pages={5563-7}
}
During the process of fertilization in mammals, sperm bind in a relatively species-specific manner to the zona pellucida (ZP) of ovulated eggs. ZP3, a glycoprotein found in the mouse egg zona pellucida, serves as receptor for sperm during gamete adhesion. We report here that a Mr 56,000 protein found on mouse sperm has properties expected for a sperm component that recognizes and binds to ZP3. This sperm protein is radiolabeled preferentially by a photoactivatable heterobifunctional crosslinker… CONTINUE READING

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