Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival.

@article{Podcheko2007IdentificationOA,
  title={Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival.},
  author={Alexey Podcheko and Paul D Northcott and George J. Bikopoulos and Andrew W Lee and Swaroop R Bommareddi and Jake A Kushner and Janet Farhang-Fallah and Maria Rozakis-Adcock},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 18},
  pages={6484-96}
}
The pleckstrin homology domain-interacting protein (PHIP) was originally identified as a 902-amino-acid (aa) protein that regulates insulin receptor-stimulated GLUT4 translocation in skeletal-muscle cells. Immunoblotting and immunohistological analyses of pancreatic beta-cells reveal prominent expression of a 206-kDa PHIP isoform restricted to the nucleus. Herein, we report the cloning of this larger, 1,821-aa isoform of PHIP (PHIP1), which represents a novel WD40 repeat-containing protein. We… CONTINUE READING