Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

  title={Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases},
  author={D. Payne and J. Hueso-Rodr{\'i}guez and H. Boyd and N. O. Concha and C. Janson and M. Gilpin and J. Bateson and C. Cheever and N. Niconovich and S. Pearson and S. Rittenhouse and D. Tew and E. D{\'i}ez and P. P{\'e}rez and J. de la Fuente and M. Rees and A. Rivera-Sagredo},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={1880 - 1886}
  • D. Payne, J. Hueso-Rodríguez, +14 authors A. Rivera-Sagredo
  • Published 2002
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT This work describes the discovery and characterization of a novel series of tricyclic natural product-derived metallo-β-lactamase inhibitors. Natural product screening of the Bacillus cereus II enzyme identified an extract from a strain of Chaetomium funicola with inhibitory activity against metallo-β-lactamases. SB236050, SB238569, and SB236049 were successfully extracted and purified from this extract. The most active of these compounds was SB238569, which possessed Ki values of 79… CONTINUE READING
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