Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor.

@article{Huot2009IdentificationOA,
  title={Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor.},
  author={M P Huot and Gillian Vogel and St{\'e}phane Richard},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 46},
  pages={31903-13}
}
Sam68, Src associated in mitosis of 68 kDa, is a known RNA-binding protein and a signaling adaptor protein for tyrosine kinases. However, the proteins associated with Sam68 and the existence of a Sam68 complex, its mass, and regulation are, however, unknown. Herein we identify a large Sam68 complex with a mass >1 MDa in HeLa cells that is composed of approximately 40 proteins using an immunoprecipitation followed by a mass spectrometry approach. Many of the proteins identified are RNA-binding… CONTINUE READING

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