Identification of a Rare 3 bp BRAF Gene Deletion in a Thyroid Nodule by Mutant Enrichment with 3'-Modified Oligonucleotides Polymerase Chain Reaction

Abstract

Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor, and 36-69% of PTC cases are caused by mutations in the BRAF gene. The substitution of a valine for a glutamic acid (V600E) comprises up to 95-100% of BRAF mutations; therefore, most diagnostic methods, including allele-specific PCR and real-time PCR, are designed to detect this… (More)
DOI: 10.3343/alm.2012.32.3.238

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@inproceedings{Jang2012IdentificationOA, title={Identification of a Rare 3 bp BRAF Gene Deletion in a Thyroid Nodule by Mutant Enrichment with 3'-Modified Oligonucleotides Polymerase Chain Reaction}, author={Mi-Ae Jang and Seung-Tae Lee and Young Lyun Oh and Sun Wook Kim and Jae Hoon Chung and Chang Seok Ki and Jong-Won Kim}, booktitle={Annals of laboratory medicine}, year={2012} }