Identification of a Polyketide Synthase Required for Alternariol (AOH) and Alternariol-9-Methyl Ether (AME) Formation in Alternaria alternata

@inproceedings{Saha2012IdentificationOA,
  title={Identification of a Polyketide Synthase Required for Alternariol (AOH) and Alternariol-9-Methyl Ether (AME) Formation in Alternaria alternata},
  author={Debjani Saha and Ramona Fetzner and Britta Burkhardt and Joachim Podlech and Manfred Metzler and Ha Dang and Christopher E. Lawrence and Reinhard Fischer},
  booktitle={PloS one},
  year={2012}
}
Alternaria alternata produces more than 60 secondary metabolites, among which alternariol (AOH) and alternariol-9-methyl ether (AME) are important mycotoxins. Whereas the toxicology of these two polyketide-based compounds has been studied, nothing is known about the genetics of their biosynthesis. One of the postulated core enzymes in the biosynthesis of AOH and AME is polyketide synthase (PKS). In a draft genome sequence of A. alternata we identified 10 putative PKS-encoding genes. The timing… CONTINUE READING
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