Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression.

@article{Rank2010IdentificationOA,
  title={Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression.},
  author={Gerhard Rank and Loretta Cerruti and Richard J. Simpson and Robert L. Moritz and Stephen M Jane and Quan Zhao},
  journal={Blood},
  year={2010},
  volume={116 9},
  pages={1585-92}
}
Defining the molecular mechanisms underpinning fetal (gamma) globin gene silencing may provide strategies for reactivation of gamma-gene expression, a major therapeutic objective in patients with beta-thalassemia and sickle cell disease (SCD). We have previously demonstrated that symmetric methylation of histone H4 Arginine 3 (H4R3me2s) by the protein… CONTINUE READING