Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway

@article{McConnell2007IdentificationOA,
  title={Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway},
  author={Jamie L McConnell and Rey J. Gomez and Lisa R McCorvey and Brian Keith Law and Brian E. Wadzinski},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={6021-6030}
}
Protein serine/threonine phosphatase 2A (PP2A) activity must be tightly controlled to maintain cell homeostasis. Here, we report the identification of a previously uncharacterized mammalian protein, type 2A-interacting protein (TIP), as a novel regulatory protein of PP2A and the PP2A-like enzymes PP4 and PP6. TIP is a ubiquitously expressed protein and parallels the distribution of the PP2A catalytic subunit. Unlike its role in yeast, TIP does not interact with the mammalian homolog of type 2A… CONTINUE READING