Identification of a Novel Small-Molecule Agonist for Human G Protein–Coupled Receptor 3

  title={Identification of a Novel Small-Molecule Agonist for Human G Protein–Coupled Receptor 3},
  author={Chenli Ye and Zhenghong Zhang and Zhilong Wang and Qiuhong Hua and Ru Zhang and Xin Xie},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  pages={437 - 443}
G protein–coupled receptor 3 (GPR3) is an orphan G protein–coupled receptor (GPCR) predominantly expressed in mammalian brain and oocytes. GPR3 plays important roles in these two organs and is known as a Gαs-coupled receptor–activated constitutively in cells. However, the signal transduction pathway and pharmacological function of GPR3 remain unclear because of the lack of a specific ligand. By use of a human embryonic kidney 293 cell line stably expressing FLAG-GPR3-green fluorescent protein… 

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