Identification of a Novel Gene Encoding a PrP-Like Protein Expressed as Chimeric Transcripts Fused to PrP Exon 1/2 in Ataxic Mouse Line with a Disrupted PrP Gene

@article{Li2000IdentificationOA,
  title={Identification of a Novel Gene Encoding a PrP-Like Protein Expressed as Chimeric Transcripts Fused to PrP Exon 1/2 in Ataxic Mouse Line with a Disrupted PrP Gene},
  author={Aimin Li and Suehiro Sakaguchi and Ryuichiro Atarashi and Bhabesh Chandra Roy and Ryota Nakaoke and Kazuhiko Arima and Nobuhiko Okimura and Juraj Kop{\'a}{\vc}ek and Kazuto Shigematsu},
  journal={Cellular and Molecular Neurobiology},
  year={2000},
  volume={20},
  pages={553-567}
}
Abstract1. Mouse lines lacking prion protein (PrPC) have a puzzling phenotypic discrepancy. Some, but not all, developed late-onset ataxia due to Purkinje cell degeneration.2. Here, we identified aberrant mRNA species in the brain of Ngsk Prnp0/0 ataxic, but not in nonataxic Zrch Prnp0/0 mouse line. These mRNAs were chimeric between the noncoding exons 1 and 2 of the PrP gene (Prnp) and the novel sequence encoding PrP-like protein (PrPLP), a putative membrane glycoprotein with 23% identity to… CONTINUE READING
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PRND (Prion Protein 2 (Dublet))

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Molecular biology of prion protein and its first homologous protein.

  • The journal of medical investigation : JMI
  • 2007
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Absence of the prion protein homologue Doppel causes male sterility.

  • The EMBO journal
  • 2002
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination.

  • Laboratory investigation; a journal of technical methods and pathology
  • 1999
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Prions

S. B. Prusiner
  • Proc. Natl. Acad. Sci. USA 95:13363–13383.
  • 1998
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Prions

S. B. Prusiner
  • Proc. Natl. Acad. Sci. USA 95:13363–13383.
  • 1998
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology.

  • Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration
  • 1994
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

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