Identification of a Novel Family of Oxidized Phospholipids That Serve as Ligands for the Macrophage Scavenger Receptor CD36*

@article{Podrez2002IdentificationOA,
  title={Identification of a Novel Family of Oxidized Phospholipids That Serve as Ligands for the Macrophage Scavenger Receptor CD36*},
  author={E. Podrez and E. Poliakov and Zhongzhou Shen and Renliang Zhang and Yijun Deng and Mingjiang Sun and Paula J Finton and L. Shan and B. Gugiu and P. Fox and H. Hoff and R. G. Salomon and S. Hazen},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={38503 - 38516}
}
The macrophage scavenger receptor CD36 plays an important role in the uptake of oxidized forms of low density lipoprotein (LDL) and contributes to lesion development in murine models of atherosclerosis. However, the structural basis of CD36 lipoprotein ligand recognition is unknown. We now identify a novel class of oxidized phospholipids that serve as high affinity ligands for CD36 and mediate recognition of oxidized forms of LDL by CD36 on macrophages. Small unilamellar vesicles of homogeneous… Expand
Structural Basis for the Recognition of Oxidized Phospholipids in Oxidized Low Density Lipoproteins by Class B Scavenger Receptors CD36 and SR-BI*
TLDR
All three positions of oxidized phospholipids are essential for the effective recognition by scavenger receptors class B, and the structure of residues in these positions controls the affinity of the binding. Expand
Specific Oxidized Phospholipids Inhibit Scavenger Receptor BI-mediated Selective Uptake of Cholesteryl Esters*
TLDR
OxPCCD36 prevent binding to SR-BI of its physiological ligand, high density lipoprotein, because of the close proximity of the binding sites for these two ligands onSR-BI, which may have an inhibitory effect on reverse cholesterol transport. Expand
Mapping and Characterization of the Binding Site for Specific Oxidized Phospholipids and Oxidized Low Density Lipoprotein of Scavenger Receptor CD36*
TLDR
Data indicate that CD36 (160-168) represents the core of the oxPCCD36 binding site with lysines 164/166 being indispensable for the binding. Expand
Analysis of relationship between oxidized phospholipid structure and interaction with the class B scavenger receptors.
TLDR
The design and synthesis of a series of model oxidized phospholipids having various functional groups at sn-1, sn-2, and sn-3 positions are described, and the correlation between their structure and their ability to serve as ligands for CD36 and SR-BI is determined. Expand
Phospholipid Hydroxyalkenals, a Subset of Recently Discovered Endogenous CD36 Ligands, Spontaneously Generate Novel Furan-containing Phospholipids Lacking CD36 Binding Activity in Vivo*
TLDR
It is confirmed that oxPC-furans, ultimately derived from phospholipids with sn-2 esterified docosahexaenoic, arachidonic, or linoleic acids, are formed during exposure of model membranes and isolated lipoproteins to physiological oxidant systems. Expand
Phospholipids in oxidized LDL not adducted to apoB are recognized by the CD36 scavenger receptor.
TLDR
It is suggested that oxPC not adducted to apoB within the intact oxLDL particle are recognized by the macrophage scavenger receptor CD36, that these lipids are not recognized by SR-A, and that they can transfer from oxidized to unoxidized LDL and induce CD36 recognition. Expand
Assessment of direct interaction between CD36 and an oxidized glycerophospholipid species.
Cluster of differentiation 36 (CD36) is a transmembrane protein that recognizes multiple diverse ligands. It is believed that (i) oxidized glycerophosphatidylcholine species having a terminalExpand
Assessment of direct interaction between CD36 and an oxidized glycerophospholipid species
Cluster of differentiation 36 (CD36) is a transmembrane protein that recognizes multiple diverse ligands. It is believed that (i) oxidized glycerophosphatidylcholine species having a terminalExpand
Scavenger receptors for oxidized and glycated proteins
TLDR
Three messages can be summarized from these experiments; endocytic uptake of OxLDL and AGE-proteins by macrophages or macrophage-derived cells is mainly mediated by SR-A and CD36, which is an important step for foam cell formation in the early stage of atherosclerosis, suggesting a potential pathological role of AGE in a HDL-mediated reverse cholesterol transport system. Expand
CD9 Tetraspanin Interacts with CD36 on the Surface of Macrophages: A Possible Regulatory Influence on Uptake of Oxidized Low Density Lipoprotein
TLDR
CD9 associates with CD36 on the macrophage surface and may participate in macrophages signaling in response to oxidized LDL, demonstrating that CD36 signals remain incompletely understood. Expand
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TLDR
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TLDR
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TLDR
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