Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms

@inproceedings{Tatsumi2015IdentificationOA,
  title={Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms},
  author={Naoya Tatsumi and Nozomi Hojo and Hiroyuki Sakamoto and Rena Inaba and Nahoko Moriguchi and Keiko Matsuno and Mari Fukuda and Akihide Matsumura and Seiji Hayashi and Soyoko Morimoto and Jun Nakata and Fumihiro Fujiki and Sumiyuki Nishida and Hiroko Nakajima and Akihiro Tsuboi and Y. Oka and Naoki Hosen and Haruo Sugiyama and Yusuke Oji and Keith William Brown},
  booktitle={PloS one},
  year={2015}
}
The Wilms' tumor gene WT1 consists of 10 exons and encodes a zinc finger transcription factor. There are four major WT1 isoforms resulting from alternative splicing at two sites, exon 5 (17AA) and exon 9 (KTS). All major WT1 isoforms are overexpressed in leukemia and solid tumors and play oncogenic roles such as inhibition of apoptosis, and promotion of cell proliferation, migration and invasion. In the present study, a novel alternatively spliced WT1 isoform that had an extended exon 4… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 54 references

Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer

S Rasheed, Nelson-ReesWA, EM Toth, P Arnstein, MB. Gardner
1974
View 9 Excerpts
Highly Influenced

Expression of the Wilms' Tumor Gene WT1 in Solid Tumors and Its Involvement in Tumor Cell Growth

Japanese journal of cancer research : Gann • 1999
View 4 Excerpts
Highly Influenced

WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy.

Japanese journal of clinical oncology • 2010
View 1 Excerpt