Identification of a New Zinc Binding Chemotype by Fragment Screening.

  title={Identification of a New Zinc Binding Chemotype by Fragment Screening.},
  author={Panagiotis K. Chrysanthopoulos and Prashant Mujumdar and Lucy A. Woods and Olan Dolezal and Bin Ren and Thomas S. Peat and Sally-Ann Poulsen},
  journal={Journal of medicinal chemistry},
  volume={60 17},
The discovery of a new zinc binding chemotype from screening a nonbiased fragment library is reported. Using the orthogonal fragment screening methods of native state mass spectrometry and surface plasmon resonance a 3-unsubstituted 2,4-oxazolidinedione fragment was found to have low micromolar binding affinity to the zinc metalloenzyme carbonic anhydrase… CONTINUE READING