Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System

@article{Johansson1999IdentificationOA,
  title={Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System},
  author={Clas B. Johansson and Stefan Momma and Diana L. Clarke and M{\aa}rten Risling and Urban Lendahl and Jonas Fris{\'e}n},
  journal={Cell},
  year={1999},
  volume={96},
  pages={25-34}
}
New neurons are continuously added in specific regions of the adult mammalian central nervous system. These neurons are derived from multipotent stem cells whose identity has been enigmatic. In this work, we present evidence that ependymal cells are neural stem cells. Ependymal cells give rise to a rapidly proliferating cell type that generates neurons that migrate to the olfactory bulb. In response to spinal cord injury, ependymal cell proliferation increases dramatically to generate migratory… Expand
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