Identification of a Microsatellite Instability Phenotype in Meningiomas1


To better understand the molecular mechanisms responsible for me mngioma tumorigenesis we previously utilized subtractive hybridization protocols to identify genes the expression or structure of which is altered in these common brain tumors. Here we show that a CA dinucleotide repeat element present in one complementary DNA isolated by this ap proach has undergone a contraction in size in a meningioma cell line. Extension of this initial observation has revealed widespread genetic alterations affecting simple repeat sequences in this and other meningio mas. These data indicate that genetic instability may play a previously unrecognizedrole in the etiologyof meningiomas.

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@inproceedings{Pykett2006IdentificationOA, title={Identification of a Microsatellite Instability Phenotype in Meningiomas1}, author={Mark J. Pykett and Maureen E Murphy and Peter R. Harnish and Donna L. George}, year={2006} }