Identification of a Leishmania infantum gene mediating resistance to miltefosine and SbIII.

@article{Choudhury2008IdentificationOA,
  title={Identification of a Leishmania infantum gene mediating resistance to miltefosine and SbIII.},
  author={Kohelia Choudhury and Dorothea Zander and Michael Kube and Richard Reinhardt and Joachim Clos},
  journal={International journal for parasitology},
  year={2008},
  volume={38 12},
  pages={1411-23}
}
Resistance to treatment is a growing problem in efforts to control Old World leishmaniasis. Parasites resistant to new therapeutics such as miltefosine have not been reported from the field yet but based on experimental evidence, may appear soon. Therefore, we attempted to identify genetic markers that may correlate with miltefosine resistance. Using a functional cloning approach, we have isolated a gene from Leishmania infantum that, upon over-expression, confers protection not only against… CONTINUE READING

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