Identification of a Kinetically Distinct Activity of 11β-Hydroxysteroid Dehydrogenase in Rat Leydig Cells.

@article{Ge1997IdentificationOA,
  title={Identification of a Kinetically Distinct Activity of 11β-Hydroxysteroid Dehydrogenase in Rat Leydig Cells.},
  author={Ren-Shan Ge and Hui-Bao Gao and Vijaya L Nacharaju and Glen L Gunsalus and Matthew Philip Hardy},
  journal={Endocrinology},
  year={1997},
  volume={138 6},
  pages={2435-2442}
}
Leydig cells are susceptible to direct glucocorticoid-mediated inhibition of testosterone biosynthesis but can counteract the inhibition through 11b-hydroxysteroid dehydrogenase (11b-HSD), which oxidatively inactivates glucocorticoids. Of the two isoforms of 11b-HSD that have been identified, type I is an NADP(H)-dependent oxidoreductase that is relatively insensitive to inhibition by end product and carbenoxolone (CBX). The type I form has been shown to be predominantly reductive in liver… CONTINUE READING

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Cloning of cDNA encoding an NAD(1)-dependent isoform of 11b-hydroxysteroid dehydrogenase in sheep kidney

  • AK Agarwal, C Monder, PC White
  • Endocr Res
  • 1995

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