Identification of a Human Heme Exporter that Is Essential for Erythropoiesis

@article{Quigley2004IdentificationOA,
  title={Identification of a Human Heme Exporter that Is Essential for Erythropoiesis},
  author={John G. Quigley and Zhantao Yang and Mark T. Worthington and John D. Phillips and Kathleen M. Sabo and Daniel E. Sabath and Carl Lansing Berg and Shigeru Sassa and Brent L Wood and Janis L. Abkowitz},
  journal={Cell},
  year={2004},
  volume={118},
  pages={757-766}
}
FLVCR, a member of the major facilitator superfamily of transporter proteins, is the cell surface receptor for feline leukemia virus, subgroup C. Retroviral interference with FLVCR display results in a loss of erythroid progenitors (colony-forming units-erythroid, CFU-E) and severe anemia in cats. In this report, we demonstrate that human FLVCR exports cytoplasmic heme and hypothesize that human FLVCR is required on developing erythroid cells to protect them from heme toxicity. Inhibition of… CONTINUE READING

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