Identification of a Human Heme Exporter that Is Essential for Erythropoiesis
@article{Quigley2004IdentificationOA, title={Identification of a Human Heme Exporter that Is Essential for Erythropoiesis}, author={John G Quigley and Zhantao Yang and Mark T. Worthington and John D Phillips and Kathleen M. Sabo and Daniel E Sabath and Carl Lansing Berg and Shigeru Sassa and Brent L. Wood and Janis L. Abkowitz}, journal={Cell}, year={2004}, volume={118}, pages={757-766} }
376 Citations
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation.
- Biology, MedicineThe Journal of clinical investigation
- 2012
Feline leukemia virus subgroup C receptor 1 regulates erythropoiesis by controlling mitochondrial heme efflux, whereas FLVCR1a expression is required to prevent hemorrhages and edema, and the aberrant expression of Flvcr1 isoforms may play a role in the pathogenesis of disorders characterized by an imbalance between heme and globin synthesis.
A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis
- Biology, MedicineScience
- 2008
It is demonstrated that FLVCR mediates heme export from macrophages that ingest senescent red cells and regulates hepatic iron, and the trafficking of heme, and not just elemental iron, facilitates erythropoiesis and systemic iron balance.
Heme Exporter FLVCR Is Required for T Cell Development and Peripheral Survival
- BiologyThe Journal of Immunology
- 2015
It is suggested that heme metabolism is particularly important in the T lineage because deletion of Flvcr in murine hematopoietic precursors caused a complete block in αβ T cell development at the CD4+CD8+ double-positive stage, although other lymphoid lineages were not affected.
Cell Development and Peripheral Survival Heme Exporter FLVCR Is Required for T
- Biology
- 2015
These studies identify a novel and unexpected role for FLVCR, a major facilitator superfamily metabolite transporter, in T cell development and suggest that heme metabolism is particularly important in the T lineage.
The Fowler Syndrome-Associated Protein FLVCR2 Is an Importer of Heme
- BiologyMolecular and Cellular Biology
- 2010
Tissue expression analysis indicates that FLVCR2 is expressed in a broad range of human tissues, including liver, placenta, brain, and kidney, which will have important implications in elucidating the pathogenic mechanisms of Fowler syndrome and of phenotypically associated disorders.
The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation
- BiologyHaematologica
- 2015
Consistently, reduction or increase of the cytosolic heme rescued the erythroid defects in zebrafish deficient in Flvcr1a or FlvCr1b, respectively, suggesting heme export represents a tightly regulated process that controls erythropoiesis.
Coordinate expression of heme and globin is essential for effective erythropoiesis.
- Biology, MedicineThe Journal of clinical investigation
- 2015
It is shown that erythropoiesis fails when heme is excessive, and the importance of evaluating Ter119(-) erythroid cells when studying erythyroid marrow failure in murine models is emphasized.
Heme and erythropoieis: more than a structural role
- Biology, MedicineHaematologica
- 2014
The regulatory role of heme during erythroid differentiation is discussed as well as the heme-mediated regulatory mechanisms that allow the orchestration of the adaptive cell response to heme deficiency.
Biology of Heme in Mammalian Erythroid Cells and Related Disorders
- Biology, MedicineBioMed research international
- 2015
The biology of heme in mammalian erythroid cells, including the heme biosynthetic pathway as well as the regulatory role of he me and human disorders that arise from defective heme synthesis are focused on.
Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster
- BiologyBMC biology
- 2022
The findings suggest a conserved heme homeostasis mechanism within insects, and between insects and mammals, and propose the fly model may be a good complement to the existing platforms of heme studies.
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