Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes

  title={Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes},
  author={Kyudong Han and Dianne I. Lou and Sara L Sawyer},
  booktitle={PLoS genetics},
Tripartite Motif (TRIM) ubiquitin ligases act in the innate immune response against viruses. One of the best characterized members of this family, TRIM5α, serves as a potent retroviral restriction factor with activity against HIV. Here, we characterize what are likely to be the youngest TRIM genes in the human genome. For instance, we have identified 11 TRIM genes that are specific to humans and African apes (chimpanzees, bonobos, and gorillas) and another 7 that are human-specific. Many of… CONTINUE READING
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