Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.

@article{Romania2017IdentificationOA,
  title={Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.},
  author={Paolo Romania and Loredana Cifaldi and Benedetta Pignoloni and Nadia Starc and Valerio D'Alicandro and Ombretta Melaiu and Giuseppina Li Pira and Ezio Giorda and Rosalba Carrozzo and Monika Bergvall and Tomas F. Bergstr{\"o}m and Lars Alfredsson and Tommy Olsson and Ingrid Kockum and Ilkka Sepp{\"a}l{\"a} and Terho Lehtim{\"a}ki and Mikko A. Hurme and Hartmut Hengel and Angela Santoni and Cristina Cerboni and Franco Locatelli and Mauro D'Amato and Doriana Fruci},
  journal={Cell reports},
  year={2017},
  volume={20 4},
  pages={
          846-853
        }
}
Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3' UTR, preserves ERAP1 from miR-UL112-5p-mediated degradation. Specifically, HCMV miR-UL112-5p binds the 3' UTR of ERAP1 A variant, but not the 3' UTR of ERAP1 G variant, and, accordingly, ERAP1 expression is reduced both at RNA and protein levels… CONTINUE READING
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