Identification of a DNA methylation signature in blood cells from persons with Down Syndrome

  title={Identification of a DNA methylation signature in blood cells from persons with Down Syndrome},
  author={Maria Giulia Bacalini and Davide Gentilini and Alessio Boattini and Enrico Giampieri and Chiara Pirazzini and Cristina Giuliani and Elisa Fontanesi and Maria Scurti and Daniel Remondini and Miriam Capri and Guido Cocchi and Alessandro Ghezzo and Alberto Del Rio and Donata Luiselli and Giovanni Vitale and Daniela Mari and Gastone C. Castellani and Mario F Fraga and Anna M. Di Blasio and Stefano Salvioli and Claudio Franceschi and Paolo Garagnani},
Down Syndrome (DS) is characterized by a wide spectrum of clinical signs, which include segmental premature aging of central nervous and immune systems. Although it is well established that the causative defect of DS is the trisomy of chromosome 21, the molecular bases of its phenotype are still largely unknown. We used the Infinium HumanMethylation450 BeadChip to investigate DNA methylation patterns in whole blood from 29 DS persons, using their relatives (mothers and unaffected siblings) as… CONTINUE READING

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Mechanism of stimulation of catalytic activity of Dnmt 3 A and Dnmt 3 B DNA ‐ ( cytosine ‐ C 5 ) ‐ methyltransferases by Dnmt 3 L

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