Identification of a DNA Segment Exhibiting Rearrangement Modifying Effects upon Transgenic δ-deleting Elements

@article{Janowski1997IdentificationOA,
  title={Identification of a DNA Segment Exhibiting Rearrangement Modifying Effects upon Transgenic δ-deleting Elements},
  author={Karen M. Janowski and Stephanie Ledbetter and Matthew S. Mayo and Richard Dean Hockett},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={91 - 100}
}
Control of the rearrangement and expression of the T cell receptor alpha and delta chains is critical for determining T cell type. The process of delta deletion is a candidate mechanism for maintaining separation of the alpha and delta loci. Mice harboring a transgenic reporter delta deletion construct show alpha/beta T cell lineage-specific use of the transgenic elements. A 48-basepair segment of DNA, termed HPS1A, when deleted from this reporter construct, loses tight lineage-specific… CONTINUE READING