Identification of a Common Protein Association Region in the Neuronal Cdk5 Activator*

@article{Wang2000IdentificationOA,
  title={Identification of a Common Protein Association Region in the Neuronal Cdk5 Activator*},
  author={X. Wang and Y. Ching and W. Lam and Z. Qi and M. Zhang and J. Wang},
  journal={The Journal of Biological Chemistry},
  year={2000},
  volume={275},
  pages={31763 - 31769}
}
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity. A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000) Gene 242, 285–294). The three proteins show competitive binding to Nck5a suggesting that they bind at a common site. The binding site has been… Expand
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