Identification of a Common Protein Association Region in the Neuronal Cdk5 Activator*

  title={Identification of a Common Protein Association Region in the Neuronal Cdk5 Activator*},
  author={X S Wang and Y P Ching and W. H. Lam and Zhong Qi and M. Zhang and J. H. Wang},
  journal={The Journal of Biological Chemistry},
  pages={31763 - 31769}
Cyclin-dependent protein kinase 5 (Cdk5) depends on the association with neuronal Cdk5 activator (Nck5a) for kinase activity. A variety of cellular proteins have been shown to undergo high affinity association with Nck5a, including three novel proteins, C42, C48, and C53 found by a yeast two-hybrid screen (Ching, Y. P., Qi, Z., and Wang, J. H. (2000) Gene 242, 285–294). The three proteins show competitive binding to Nck5a suggesting that they bind at a common site. The binding site has been… 

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