Identification of a Breast Cancer Associated Regulatory Network

@article{Parvin2009IdentificationOA,
  title={Identification of a Breast Cancer Associated Regulatory Network},
  author={Jeffrey D. Parvin and Zeina Kais and Mansi Arora and Shweta Kotian and Alicia M. Zha and Derek J R Ransburgh and Doruk Bozdag and Umit V. Catalyurek and K. M. Huang},
  journal={2009 Ohio Collaborative Conference on Bioinformatics},
  year={2009},
  pages={71-75}
}
We are developing a new framework for discovery of genes involved in the breast carcinogenesis process. Among families that have a predisposition to breast cancer, approximately 25% have inherited mutations in either breast cancer associated (“BRCA”) genes BRCA1 or BRCA2, but the predisposing mutated genes in the majority of the families are unknown. BRCA1 and BRCA2 gene products both regulate cellular pathways that involve DNA repair and centrosome duplication, and their expression is… CONTINUE READING

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