Identification of a B cell signature associated with renal transplant tolerance in humans.

@article{Newell2010IdentificationOA,
  title={Identification of a B cell signature associated with renal transplant tolerance in humans.},
  author={K. Newell and A. Asare and A. Kirk and Trang D. Gisler and K. Bourcier and M. Suthanthiran and W. Burlingham and W. Marks and I. Sanz and R. Lechler and M. Hernandez-Fuentes and L. Turka and V. Seyfert-Margolis},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 6},
  pages={
          1836-47
        }
}
Establishing long-term allograft acceptance without the requirement for continuous immunosuppression, a condition known as allograft tolerance, is a highly desirable therapeutic goal in solid organ transplantation. Determining which recipients would benefit from withdrawal or minimization of immunosuppression would be greatly facilitated by biomarkers predictive of tolerance. In this study, we identified the largest reported cohort to our knowledge of tolerant renal transplant recipients, as… Expand
568 Citations

Paper Mentions

Observational Patient Registry Clinical Trial
The purpose of this study is to understand the role of specific B cells in activating or repressing an anti-allograft immune response after kidney transplantation. In this study… Expand
ConditionsKidney; Complications, Allograft, Transplantation Infection
InterventionDrug
Observational Clinical Trial
The purpose of this multi-center (observational) registry study is to establish a database of clinical and laboratory information that may help to identify any unique characteristics of… Expand
ConditionsKidney Transplantation, Renal Transplant, Renal Transplantation, (+2 more)
Observational Clinical Trial
This is an observational study for people who have received a kidney transplant within the past 1 to 5 years. Researchers in this study are looking for a certain pattern of genes and… Expand
ConditionsKidney Transplantation
Longitudinal Studies of a B Cell–Derived Signature of Tolerance in Renal Transplant Recipients
  • K. Newell, A. Asare, +20 authors L. Turka
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2015
  • 63
  • PDF
B Cell Receptor Genes Associated With Tolerance Identify a Cohort of Immunosuppressed Patients With Improved Renal Allograft Graft Function
  • A. Asare, S. Kanaparthi, +14 authors L. Turka
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2017
  • 21
  • PDF
Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans.
  • 458
  • PDF
Matchmaking the B‐Cell Signature of Tolerance to Regulatory B Cells
  • A. Chong, R. Sciammas
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2011
  • 18
  • Highly Influenced
Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?
  • 64
  • PDF
Validation Study of an Operational Tolerance Signature in Korean Kidney Transplant Recipients
  • 3
  • Highly Influenced
  • PDF
A Need for Biomarkers of Operational Tolerance in Liver and Kidney Transplantation
  • 44
B Cell Markers of Operational Tolerance Can Discriminate Acute Kidney Allograft Rejection From Stable Graft Function
  • 22
  • Highly Influenced
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References

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Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans.
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