Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane.

@article{Scherer1992IdentificationOA,
  title={Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane.},
  author={Phillip E Scherer and U C Manning-Krieg and Paul Jenoe and Gottfried Schatz and Melinda J. Horst},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 24},
  pages={
          11930-4
        }
}
Import of proteins into mitochondria involves the cooperation of protein translocation systems in the outer and inner membranes. We have identified a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane. This 45-kDa protein could be crosslinked to a partly translocated precursor, which cannot be imported across the inner membrane when the matrix is depleted of ATP. In addition, an antibody against this protein strongly inhibited protein import into right-side-out… CONTINUE READING
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