Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma.

@article{Agnelli2012IdentificationOA,
  title={Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma.},
  author={Luca Agnelli and Elisabetta Mereu and Elisa Pellegrino and Tania Limongi and Ivo Kwee and Elisa Bergaggio and Maurilio Ponzoni and Alberto Zam{\`o} and Javeed Iqbal and Pier Paolo Piccaluga and Antonino Neri and Wing Chung Chan and Stefano A Pileri and Francesco Bertoni and Giorgio Inghirami and Roberto Piva},
  journal={Blood},
  year={2012},
  volume={120 6},
  pages={1274-81}
}
Anaplastic large-cell lymphomas (ALCLs) are a group of clinically and biologically heterogeneous diseases including the ALK(+) and ALK(-) systemic forms. Whereas ALK(+) ALCLs are molecularly characterized and can be readily diagnosed, specific immunophenotypic or genetic features to define ALK(-) ALCL are missing, and their distinction from other T-cell non-Hodgkin lymphomas (T-NHLs) remains controversial. In the present study, we undertook a transcriptional profiling meta-analysis of 309 cases… CONTINUE READING