Identification of a 23S rRNA gene mutation in clarithromycin-resistant Helicobacter pylori.


BACKGROUND Transition mutations (A-G) at residue 2143, cognate to position 2058 in the Escherichia coli 23S rRNA gene, have been shown to confer resistance to macrolides in Helicobacter pylori. This study reports the finding that transversion mutations (A-C) can occur at 2143 as well. MATERIALS AND METHODS Three clarithromycin-resistant H. pylori isolated… (More)


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