Identification of a δ isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes

@article{Lai1998IdentificationOA,
  title={Identification of a δ isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes},
  author={Jian-ping Lai and Steven D. Douglas and E. Rappaport and Jessie M. Wu and Wen-zhe Ho},
  journal={Journal of Neuroimmunology},
  year={1998},
  volume={91},
  pages={121-128}
}
We have characterized preprotachykinin (PPT-A) gene transcript splicing products and identified a fourth isoform of PPT-A mRNA transcript in human peripheral blood-isolated monocytes and PBL. Using RT-PCR, Southern blot analysis and nucleotide sequencing analysis, we have identified the four isoforms of PPT-A transcripts (alpha, beta, gamma and delta) in human peripheral blood-isolated monocytes and PBL. The delta-PPT transcript present in the immune cells lacks exons 4 and 6. The sequences of… CONTINUE READING

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