Identification of Virus-Encoded MicroRNAs

@article{Pfeffer2004IdentificationOV,
  title={Identification of Virus-Encoded MicroRNAs},
  author={S{\'e}bastien Pfeffer and Mihaela Zavolan and Friedrich A Gr{\"a}sser and Minchen Chien and James J. Russo and Jingyue Ju and Bino John and Anton J. Enright and Debora S. Marks and Chris Sander and Thomas Tuschl},
  journal={Science},
  year={2004},
  volume={304},
  pages={734 - 736}
}
RNA silencing processes are guided by small RNAs that are derived from double-stranded RNA. To probe for function of RNA silencing during infection of human cells by a DNA virus, we recorded the small RNA profile of cells infected by Epstein-Barr virus (EBV). We show that EBV expresses several microRNA (miRNA) genes. Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for degradation or by repressing translation, we identified viral regulators of host and/or… Expand
An overview of RNA virus-encoded microRNAs
TLDR
This work focuses on the miRNAs encoded by RNA virus and discusses their potential role in viral replication cycle and host cells. Expand
Retroviral microRNAs.
TLDR
This work will focus on the retrovirus family, HIV-1 in particular, and discuss the production of virus-encoded miRNAs and their putative function in the viral replication cycle. Expand
Induction and suppression of RNA silencing: insights from viral infections
  • O. Voinnet
  • Biology, Medicine
  • Nature Reviews Genetics
  • 2005
TLDR
These studies have not only highlighted the basic understanding of host–parasite interactions, but also provide key insights into the diversity, regulation and evolution of RNA-silencing pathways. Expand
Role of virus-encoded microRNAs in herpesvirus biology.
TLDR
The subject of this review will be the herpesvirus miRNAs and their respective target genes that have been determined experimentally to date. Expand
Identification of virally encoded microRNAs.
  • S. Pfeffer
  • Biology, Medicine
  • Methods in enzymology
  • 2007
TLDR
This work has shown that mammalian viruses exploit the host RNA silencing machinery to produce miRNAs that have the potential to act both on the infected host genome and on the viral genome. Expand
Identification and characterization of small RNAs involved in RNA silencing
TLDR
The experimental and bioinformatic approaches that were used to identify and characterize these small RNAs isolated from cells and tissues are reviewed. Expand
MicroRNAs in viral replication and pathogenesis.
TLDR
This review will focus on the recent efforts to understand the complex relationship between vertebrate viruses and the RNAi pathway, as well as the role of silencing pathways in the inhibition of pathogenic genetic elements, including transposons and retrotransposons. Expand
MicroRNAs and Oncogenic Human Viruses
TLDR
The roles of virally-regulated cellular miRNAs in the respective viral life-cycles and in virus-related tumors are discussed. Expand
Antiviral Immunity Directed by Small RNAs
TLDR
The proteins required for viRNA production as well as several key downstream components of the antiviral immunity pathway have been identified in plants, flies, and worms, illuminating an ongoing molecular arms race that likely impacts the evolution of both viral and host genomes. Expand
Role of siRNAs and miRNAs in the processes of RNA-mediated gene silencing during viral infections
TLDR
The main stages of gene silencing mechanism, features of antiviral RNA silencing in plants, invertebrates, mammals, ways of suppression of RNA-interference by viruses, as well as possible approaches of utilization of abovementioned phenomenon for struggling against viral infections are described. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 12 REFERENCES
Induction and Suppression of RNA Silencing by an Animal Virus
TLDR
It is shown that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNAsilencing by an FHv-encoded protein, B2. Expand
RNA silencing as a plant immune system against viruses.
  • O. Voinnet
  • Biology, Medicine
  • Trends in genetics : TIG
  • 2001
TLDR
"RNA silencing" refers to related processes of post-trancriptional control of gene expression found in plants, animals and fungi, which serves as an adaptive, antiviral defence system, which is transmitted systemically in response to localized virus challenge. Expand
A uniform system for microRNA annotation.
TLDR
Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that mi RNAs can be reliably distinguished from other RNAs such as small interfering RNAs. Expand
A microRNA in a Multiple-Turnover RNAi Enzyme Complex
TLDR
It is shown that, in human cell extracts, the miRNA let-7 naturally enters the RNAi pathway, which suggests that only the degree of complementarity between a miRNA and its RNA target determines its function. Expand
MicroRNAs Genomics, Biogenesis, Mechanism, and Function
TLDR
Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes. Expand
Expression of the complementary-strand transcripts from BamHI-A region of the Epstein-Barr virus genome in various induced virus-carrying B cell lines.
TLDR
This work investigates its transcription in several EBV-carrying B cell lines during different viral stages and shows that at least some of the BARF0 transcripts are transcribed during the viral lytic stage in the tested inducible lines. Expand
Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA.
TLDR
Results indicate that the mRNA encoded by the Epstein-Barr virus DNA polymerase gene is polyadenylylated at two different termini without the use of canonical signals, raising the possibility of involvement of a virus-encoded factor in 3' processing of this message. Expand
Pathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disorders.
TLDR
In the following pages, an overview of the biology of EBV-infection is given and functional aspects of EBv-proteins are discussed and their putative role in the variousEBV-associated disorders is described. Expand
BHRF1, the Epstein-Barr virus (EBV) homologue of the BCL-2 protooncogene, is transcribed in EBV-associated B-cell lymphomas and in reactive lymphocytes.
TLDR
The consistent transcription of BHRF1 in EBV-associated B-cell lymphomas suggests a possible pathogenic role for this gene product inEBV-positive B- cell lymphomas analogous to bcl-2. Expand
BCL-2 but not its Epstein-Barr virus-encoded homologue, BHRF1, is commonly expressed in posttransplantation lymphoproliferative disorders.
TLDR
A role for the EBV homologue of BCL-2 in PTLD is not supported, but results do support a role for viral induction of B CL-2 expression. Expand
...
1
2
...