Identification of Vibrio cholerae type III secretion system effector proteins.

@article{Alam2011IdentificationOV,
  title={Identification of Vibrio cholerae type III secretion system effector proteins.},
  author={Ashfaqul Alam and Kelly Anne Miller and Mudit Chaand and James Scott Butler and Michelle Dziejman},
  journal={Infection and immunity},
  year={2011},
  volume={79 4},
  pages={
          1728-40
        }
}
AM-19226 is a pathogenic O39 serogroup Vibrio cholerae strain that lacks the typical virulence factors for colonization (toxin-coregulated pilus [TCP]) and toxin production (cholera toxin [CT]) and instead encodes a type III secretion system (T3SS). The mechanism of pathogenesis is unknown, and few effector proteins have been identified. We therefore undertook a survey of the open reading frames (ORFs) within the ∼49.7-kb T3SS genomic island to identify potential effector proteins. We… CONTINUE READING

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