Identification of Unstable Network Modules Reveals Disease Modules Associated with the Progression of Alzheimer’s Disease

@inproceedings{Kikuchi2013IdentificationOU,
  title={Identification of Unstable Network Modules Reveals Disease Modules Associated with the Progression of Alzheimer’s Disease},
  author={Masataka Kikuchi and Soichi Ogishima and Tadashi Miyamoto and Akinori Miyashita and Ryozo Kuwano and Jun Nakaya and Hiroshi Tanaka},
  booktitle={PloS one},
  year={2013}
}
Alzheimer's disease (AD), the most common cause of dementia, is associated with aging, and it leads to neuron death. Deposits of amyloid β and aberrantly phosphorylated tau protein are known as pathological hallmarks of AD, but the underlying mechanisms have not yet been revealed. A high-throughput gene expression analysis previously showed that differentially expressed genes accompanying the progression of AD were more down-regulated than up-regulated in the later stages of AD. This suggested… CONTINUE READING